Endocrine Abstracts

Introduction: Acromegaly is a rare endocrine disorder. In 95% of cases, it is caused by a GH-secreting pituitary adenoma. Rarely, acromegaly is due to ectopic production of GH or growth hormone-releasing hormone (GHRH). Herein, we report a case of acromegaly with negative pituitary magnetic resonance imaging (MRI) and discuss its possible etiology and management.Observation: A 75-year-old woman was referred to our department for the exploration of acquir...

Introduction: Hyperprolactinemia is a condition of elevated prolactin levels in blood which could be physiological, pathological, or idiopathic in origin. Some cases of hyperprolactinemia have been reported in patients with renal failure. We present a case of hyperprolactinemia, thyrotropic and corticotropic insufficiency in a patient with end-stage renal failure.Case presentation: The patient was 27 years old, with a history of hypertension, renal insuf...

Introduction: Ectopic thyroid gland is a rare pathology due to an abnormality in the embryological development and/or migration of the gland. The aim of this study was to assess clinical and paraclinical characteristics of adult patients with ectopic thyroid gland.Methods: This was a retrospective study including adult patients with ectopic thyroid gland. Clinical, biological, hormonal, radiological and therapeutic data were collected.<p class="abste...

Long fasting in patients with adrenal insufficiency could cause hypotension, dehydration or hypoglycaemia. No studies evaluated these risks and there is no recommendations about fasting for these patients. The aim of our study was to evaluate the potential risks of fasting during the month of Ramadan in patients with adrenal insufficiency.Subjects and methods: It is a cross sectional study that concerned 125 subjects (97 women and 28 men, mean age=47.8 y...

IntroductionPrimary hyperaldosteronism (PHA) is an increasingly prevalent cause of endocrine hypertension. It is characterized by unregulated aldosterone secretion with an excessive activation of mineralocorticoid receptors, inducing volume expansion, hypokalemia, endothelial dysfunction and fibrotic processes in the renal and cardiovascular systems. The aim of this study was to assess the metabolic, renal, and cardiovascular status in patients with prim...

IntroductionPrimary hyperaldosteronism (PHA) represents the most common cause of secondary hypertension. It is associated with a high risk of cardiovascular diseases (CVD), suggesting that aldosterone is implicated in the development of early atherosclerosis. Clinical studies have shown that atherogenic index of plasma (AIP) predicts cardiovascular risk. The aim of this study was to assess the associations between atherogenic index of plasma and cardiova...

IntroductionCurrent standard treatment of primary hypoparathyroidism is based on calcium and activated vitamin D supplementation. Iatrogenic severe hypercalcemia due to vitamin D intoxication is an uncommon complication rarely described in literature. Herein we report 5 cases of severe hypercalcemia secondary to vitamin D intoxication.ObservationsThree men and two women with chronic hypoparathyroidism were in...

IntroductionHyponatremia secondary to the syndrome of inappropriate anti diuretic hormone (SIADH) secretion is one of the most frequently observed electrolyte abnormalities in coronavirus disease -2019 (COVID-19). Herein, we report a new case of SIADH in a type 2 diabetic patient with COVID-19 pneumonia.ObservationA 79-year-old man with type 2 diabetes mellitus was admitted for a poor general condition. On ph...

IntroductionAcromegaly is an endocrine disorder resulting from an excess of growth hormone (GH). The cause is almost always a pituitary adenoma, and it affects through the insulin-like Growth Factor 1 (IGF-1) the cellular proliferation, increasing therefore the risk of malignancy. Herein, we describe a case of coexistence of papillary thyroid carcinoma and primary hyperparathyroidism in a patient with acromegaly.Case report<p c...

Introduction: Glycaemic control is still difficult to achieve despite advances in the pharmacotherapy of type 2 diabetes. Moreover, the COVID-19 crisis led to a disruption in medical consultations and in the access to medications. The aim of our study was to identify factors associated with poor glycaemic control in Tunisian type 2 diabetic patients during the COVID-19 crisis.Methods: This is a cross-sectional study, carried out in December 2021, on type...